Mapping the Connectome That Controls Blood Pressure

Prebötzinger complex neurons drive respiratory modulation of blood pressure and heart rate

C Menuet, AA Connelly, JK Bassi, MR Melo, S Le, J Kamar, NN Kumar, SJ McDougall, S McMullan, AM Allen

2020-06-01

Heart rate and blood pressure oscillate in phase with respiratory activity. A component of these oscillations is generated central..

On the presence and functional significance of sympathetic premotor neurons with collateralized spinal axons in the rat

DGS Farmer, N Pracejus, B Dempsey, A Turner, P Bokiniec, JFR Paton, AE Pickering, J Burguet, P Andrey, AK Goodchild, RM McAllen, S McMullan

2019-07-01

Key points: Spinally-projecting neurons of the rostral ventrolateral medulla (RVLM) determine sympathetic outflow to different ter..

Excessive Respiratory Modulation of Blood Pressure Triggers Hypertension

C Menuet, S Le, B Dempsey, AA Connelly, JL Kamar, N Jancovski, JK Bassi, K Walters, AE Simms, A Hammond, AY Fong, AK Goodchild, S McMullan, AM Allen

2017-03-07

The etiology of hypertension, the world's biggest killer, remains poorly understood, with treatments targeting the established sym..

Mapping and analysis of the connectome of sympathetic premotor neurons in the rostral ventrolateral medulla of the rat using a volumetric brain atlas

B Dempsey, S Le, A Turner, P Bokiniec, R Ramadas, JG Bjaalie, C Menuet, R Neve, AM Allen, AK Goodchild, S McMullan

2017-03-01

Spinally projecting neurons in the rostral ventrolateral medulla (RVLM) play a critical role in the generation of vasomotor sympat..

Polysialic acid regulates sympathetic outflow by facilitating information transfer within the nucleus of the solitary tract

P Bokiniec, S Shahbazian, SJ McDougall, BA Berning, D Cheng, IJ Llewellyn-Smith, PGR Burke, S McMullan, M Mühlenhoff, H Hildebrandt, F Braet, M Connor, NH Packer, AK Goodchild

2017-01-01

Expression of the large extracellular glycan, polysialic acid (polySia), is restricted in the adult, to brain regions exhibiting h..

Recording, labeling, and transfection of single neurons in deep brain structures

B Dempsey, AJ Turner, S Le, QJ Sun, LB Farah, AM Allen, AK Goodchild, S McMullan

2015-01-01

Genetic tools that permit functional or connectomic analysis of neuronal circuits are rapidly transforming neuroscience. The key t..

Orexinergic activation of medullary premotor neurons modulates the adrenal sympathoexcitation to hypothalamic glucoprivation

WS Korim, LB Farah, S McMullan, AJM Verberne

2014-01-01

Glucoprivation activates neurons in the perifornical hypothalamus (PeH) and in the rostral ventrolateral medulla (RVLM), which res..

Noxious somatic stimuli diminish respiratory-sympathetic coupling by selective resetting of the respiratory rhythm in anaesthetized rats

WS Korim, E Egwuenu, AY Fong, S Mcmullan, SL Cravo, PM Pilowsky

2012-01-01

Noxious somatic stimulation evokes respiratory and autonomic responses. The mechanisms underlying the responses and the manner in ..